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Arthur J L Cooper Selected Research

Glutamine (L-Glutamine)

8/2023Metabolic Heterogeneity, Plasticity, and Adaptation to "Glutamine Addiction" in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase-ω-Amidase (Glutaminase II)] Pathway.
1/2022The metabolic importance of the glutaminase II pathway in normal and cancerous cells.
1/2022α-Ketoglutaramate-A key metabolite contributing to glutamine addiction in cancer cells.
12/2019High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'.
11/2019Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
12/2016Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.
3/2016Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain.
1/2016ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.
12/2015Erratum to: ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.
12/2015Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke.
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Arthur J L Cooper Research Topics

Disease

21Neoplasms (Cancer)
08/2023 - 01/2005
9Huntington Disease (Huntington's Disease)
09/2010 - 01/2002
8Hyperammonemia
06/2017 - 10/2010
6Neurodegenerative Diseases (Neurodegenerative Disease)
01/2011 - 01/2002
5Liver Diseases (Liver Disease)
06/2017 - 10/2010
4Brain Diseases (Brain Disorder)
06/2013 - 02/2006
3Hepatic Encephalopathy
06/2017 - 10/2012
2Carcinogenesis
01/2023 - 11/2019
2Prostatic Neoplasms (Prostate Cancer)
12/2019 - 07/2009
2Scrapie
05/2015 - 07/2014
2Lysinuric Protein Intolerance
12/2014 - 06/2011
2Adult-onset citrullinemia type 2
12/2014 - 06/2011
2Hypertension (High Blood Pressure)
06/2014 - 06/2004
2Acute Liver Failure (Fulminant Hepatic Failure)
11/2011 - 10/2010
2Alzheimer Disease (Alzheimer's Disease)
07/2009 - 04/2004
2Mitochondrial Diseases (Mitochondrial Disease)
10/2005 - 08/2002
1Acquired Immunodeficiency Syndrome (AIDS)
08/2023
1Kidney Calculi (Kidney Stone)
01/2022
1Leukemia
01/2022
1Lymphoma (Lymphomas)
11/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2019
1Cysts
10/2018
1Fibrosis (Cirrhosis)
01/2016
1Stroke (Strokes)
12/2015
1Reperfusion Injury
12/2015
1Pre-Eclampsia (Preeclampsia)
06/2014
1Edema (Dropsy)
06/2013
1Ulcer
09/2012
1Duodenal Ulcer (Curling's Ulcer)
09/2012
1Neurologic Manifestations (Neurological Manifestations)
11/2011
1Citrullinemia
06/2011

Drug/Important Bio-Agent (IBA)

21Glutamine (L-Glutamine)FDA Link
08/2023 - 06/2004
15EnzymesIBA
01/2022 - 08/2002
8Proteins (Proteins, Gene)FDA Link
01/2017 - 01/2002
7amidaseIBA
08/2023 - 09/2009
7Glutamic Acid (Glutamate)FDA Link
11/2021 - 06/2011
7NitrogenIBA
01/2016 - 08/2009
5TransglutaminasesIBA
10/2018 - 01/2002
5AmmoniaIBA
06/2017 - 10/2010
5AsparagineIBA
01/2016 - 08/2009
4glutamine-pyruvate aminotransferaseIBA
08/2023 - 11/2019
4Biomarkers (Surrogate Marker)IBA
10/2018 - 06/2011
4SulfurIBA
01/2016 - 01/2005
4Urea (Carbamide)FDA LinkGeneric
12/2014 - 06/2011
3Cysteamine (Mercaptamine)FDA Link
10/2018 - 04/2004
3Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
12/2015 - 10/2010
3AcidsIBA
06/2011 - 07/2009
3CystamineIBA
08/2005 - 10/2002
2GlutaminaseIBA
08/2023 - 11/2019
2CarbonIBA
01/2022 - 11/2021
2glutamine - phenylpyruvate transaminaseIBA
12/2019 - 11/2019
2AminesIBA
10/2018 - 05/2015
2nitrilaseIBA
01/2017 - 07/2012
2Oxygen (Dioxygen)IBA
12/2015 - 04/2007
2IminesIBA
05/2015 - 07/2014
2Amino AcidsFDA Link
05/2015 - 06/2011
2Protein Glutamine gamma Glutamyltransferase 2IBA
09/2010 - 10/2005
2omega-amidaseIBA
09/2009 - 08/2009
2Cysteine (L-Cysteine)FDA Link
01/2006 - 01/2005
2AntioxidantsIBA
01/2005 - 04/2004
1Antineoplastic Agents (Antineoplastics)IBA
08/2023
1CalciumIBA
01/2022
1glyoxylic acid (glyoxylate)IBA
01/2022
1Asparaginase (Elspar)FDA Link
01/2022
1OxalatesIBA
01/2022
1SaltsIBA
01/2022
1Lactic Acid (Lactate)FDA LinkGeneric
11/2021
1gamma-Aminobutyric Acid (GABA)IBA
11/2021
1isospaglumic acid (NAAGA)IBA
11/2021
1IsotopesIBA
11/2021
1Succinic Acid (Succinate)IBA
11/2021
1Glucose (Dextrose)FDA LinkGeneric
11/2021
1FumaratesIBA
01/2018
1Sulfhydryl Compounds (Thiols)IBA
01/2018
1Glutamate DehydrogenaseIBA
03/2016
1AmidesIBA
03/2016
1Folic Acid (Vitamin M)FDA LinkGeneric
01/2016
1Extracellular Matrix ProteinsIBA
01/2016
14,5-dihydroorotic acidIBA
05/2015
1Arginine (L-Arginine)FDA Link
05/2015
1PyridoxalIBA
05/2015
1Threonine Dehydratase (Threonine Ammonia-Lyase)IBA
05/2015
1Carbamyl Phosphate (Carbamoyl Phosphate)IBA
05/2015
1Oxidoreductases (Dehydrogenase)IBA
05/2015
1HydrolasesIBA
05/2015
1Branched-Chain Amino AcidsIBA
07/2014
1Green Fluorescent ProteinsIBA
07/2014
1Hydro-Lyases (Dehydratases)IBA
07/2014
1preemptIBA
07/2014
1Transaminases (Aminotransferases)IBA
07/2014
1CystathionineIBA
06/2014
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
06/2014
1LyasesIBA
06/2014
1IronIBA
09/2012
1Coenzyme A (CoA)IBA
09/2012
1Acetaminophen (Paracetamol)FDA LinkGeneric
11/2011
1Aspartic Acid (Aspartate)FDA Link
06/2011
1Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA
06/2011

Therapy/Procedure

3Therapeutics
01/2023 - 11/2011
1Radiotherapy
01/2023